The Population Genetics of Synthetic Lethals

The population genetics of synthetic lethals.

Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL under a mutation-selection balance for the complete haploid model and selected cases of the dipl...

The population genetics of X-autosome synthetic lethals and steriles.

Epistatic interactions are widespread, and many of these interactions involve combinations of alleles at different loci that are deleterious when present in the same individual. The average genetic environment of sex-linked genes differs from that of autosomal genes, suggesting that the population genetics of interacting X-linked and autosomal alleles may be complex. Using both analytical theor...

DAISY: picking synthetic lethals from cancer genomes.

A better understanding of genetic interactions in cancer might help identify new therapeutic approaches that exploit the concept of synthetic lethality. Ruppin and colleagues have developed a new computational method, DAISY, that predicts such interactions and potentially facilitates the delineation and validation of comprehensive genetic interaction networks.

The Problem of Synthetic Lethals in Drosophila Melanogaster.

Quantitative Genetics of Inbreeding in a Synthetic Maize Population

genetic values of independent lines with inbreeding have revealed large variability among lines (Bartual and HalThe average effects of inbreeding depression have been measured lauer, 1976; Cornelius and Dudley, 1974, 1976; Obilana extensively in maize (Zea mays L.), but the influence of inbreeding and Hallauer, 1974) and variability in inbreeding depreson genetic variance has not been well stud...